diff --git a/xen/arch/x86/mm/p2m-pt.c b/xen/arch/x86/mm/p2m-pt.c
index 12f92cf1f0..52eaa24b18 100644
--- a/xen/arch/x86/mm/p2m-pt.c
+++ b/xen/arch/x86/mm/p2m-pt.c
@@ -479,6 +479,23 @@ int p2m_pt_handle_deferred_changes(uint64_t gpa)
     return rc;
 }
 
+/* Checks only applicable to entries with order > PAGE_ORDER_4K */
+static void check_entry(mfn_t mfn, p2m_type_t new, p2m_type_t old,
+                        unsigned int order)
+{
+    ASSERT(order > PAGE_ORDER_4K);
+    ASSERT(old != p2m_ioreq_server);
+    if ( new == p2m_mmio_direct )
+        ASSERT(!mfn_eq(mfn, INVALID_MFN) &&
+               !rangeset_overlaps_range(mmio_ro_ranges, mfn_x(mfn),
+                                        mfn_x(mfn) + (1ul << order)));
+    else if ( p2m_allows_invalid_mfn(new) || new == p2m_invalid ||
+              new == p2m_mmio_dm )
+        ASSERT(mfn_valid(mfn) || mfn_eq(mfn, INVALID_MFN));
+    else
+        ASSERT(mfn_valid(mfn));
+}
+
 /* Returns: 0 for success, -errno for failure */
 static int
 p2m_pt_set_entry(struct p2m_domain *p2m, gfn_t gfn_, mfn_t mfn,
@@ -575,8 +592,7 @@ p2m_pt_set_entry(struct p2m_domain *p2m, gfn_t gfn_, mfn_t mfn,
             }
         }
 
-        ASSERT(p2m_flags_to_type(flags) != p2m_ioreq_server);
-        ASSERT(!mfn_valid(mfn) || p2mt != p2m_mmio_direct);
+        check_entry(mfn, p2mt, p2m_flags_to_type(flags), page_order);
         l3e_content = mfn_valid(mfn) || p2m_allows_invalid_mfn(p2mt)
             ? p2m_l3e_from_pfn(mfn_x(mfn),
                                p2m_type_to_flags(p2m, p2mt, mfn, 2))
@@ -667,8 +683,7 @@ p2m_pt_set_entry(struct p2m_domain *p2m, gfn_t gfn_, mfn_t mfn,
             }
         }
 
-        ASSERT(p2m_flags_to_type(flags) != p2m_ioreq_server);
-        ASSERT(!mfn_valid(mfn) || p2mt != p2m_mmio_direct);
+        check_entry(mfn, p2mt, p2m_flags_to_type(flags), page_order);
         l2e_content = mfn_valid(mfn) || p2m_allows_invalid_mfn(p2mt)
             ? p2m_l2e_from_pfn(mfn_x(mfn),
                                p2m_type_to_flags(p2m, p2mt, mfn, 1))